Strong Transthyretin Immunostaining

Immunostaining of skeletal tissues.

Immunohistochemistry (IHC) is a routinely used technique in clinical diagnosis of pathological conditions and in basic research. It combines anatomical, immunological, and biochemical methods and relies on the specific binding of an antibody to an antigen. Using the technique with mineralised tissues is more complicated than with soft tissues. This can in most cases be overcome by demineralisin...

IgA Nephropathy and Significance of Immunostaining Data

Immunostaining with dissociable antibody microarrays.

The availability of a large number of biological materials such as cDNA, antibodies, recombinant proteins, and tissues has promoted the development of microarray technologies that make use of these materials in high-throughput screening assays. However, because microarray technologies have been less successful in examining proteins than DNA and mRNA, there is a need for improved protein microar...

Transthyretin Amyloidosis – an Overview

Familial amyloidosis describes a group of late-onset autosomal dominant diseases with amyloid protein deposition occurring in various tissues throughout the body and in the bloodstream (reviewed in (1)). Transthyretin Amyloidosis (ATTR), the most common familial amyloidosis, is associated with mutations in the TTR gene and is generally characterized by progressive neuropathy, cardiomyopathy, ne...

VS38 immunostaining in melanocytic lesions.

AIMS To investigate the immunoreactivity of a range of melanocytic lesions, both benign and malignant, with the monoclonal antibody VS38. This was recently described as a marker of reactive/neoplastic plasma cells and, therefore, is useful in the diagnosis of plasmacytoma/myeloma and lymphomas with plasmacytic differentiation. This study was prompted by the recent observation that a plasmacytoi...